IVIVC for Extended Release Hydrophilic Matrix Tablets in Consideration of Biorelevant Mechanical Stress

Optimization of extended-release hydrophilic matrix tablets by support vector regression.

BACKGROUND In this work, support vector regression (SVR) was applied to the optimization of extended release from swellable hydrophilic pentoxifylline matrix-tablets and compared to multiple linear regression (MLR). METHODS Binary mixtures comprising ethylcellulose and sodium alginate were used as the matrix-former. The matrix-former : drug weight ratio and the percentage of sodium alginate i...

Preparation of Alprazolam Extended- Release Tablets and In vitro Characterization

Abstract The main aim of this study was to prepare and evaluate the extended - release system of an anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. Our studies focused on the development of extended drug delivery system based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent and polyvinylpyrrolidone (PVP k30...

Use of Roller Compaction in the Preparation of Verapamil Hydrochloride Extended Release Matrix Tablets Containing Hydrophilic Polymers

SUMMARY Roller compacted hydrophilic polymer combinations were used to formulate verapamil hydrochloride (HCl) extended release hydrophilic matrix tablets. The effect of roller compaction (RC) parameters on the properties of blended polymers, tablets and drug release were investigated. RC granulation improved the powder properties without affecting the pharmacotechnical properties or the drug r...

preparation and evaluation of zinc sulfate sustained release tablets using lipophilic and hydrophilic matrix

Effect of Quaternary Ammonium Carboxymethylchitosan on Release Rate In-vitro of Aspirin Sustained-release Matrix Tablets

The aim of this study was to develop a derivative of chitosan as pharmaceutical excipient used in sustained-release matrix tablets of poorly soluble drugs. A water-soluble quaternary ammonium carboxymethylchitosan was synthesized by a two-step reaction with carboxymethylchitosan (CMCTS), decylalkyl dimethyl ammonium and epichlorohydrin. The elemental analysis showed that the target product with...